S-Adenosyl-L-methionine（SAMe）is a ramification of L-methionine, which is a biological compound involved in methyl group transfers. It is present in all living cells and is a very important active substance in the human body. Transmethylation, transulfuration and aminopropylation are the metabolic pathways that use SAMe. It is the precursor of cysteine, taurine, glutathione and coenzyme A. Most SAMe is produced and consumed in the liver and synthesized endogenously from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase.

Function:

Joint Strength
SAM-e supports the production of healthy connective tissue through transsulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e.
Brain Metabolism
SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa, dopamine and related hormones, epinephrine and phosphatidylcholine (a component of Lecithin).
Longevity
Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influence longevity.